Flu genes help clarify 1918 pandemic
USA Today
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... mutations enabled the virus to fix itself firmly to umbrella-shaped receptors in the respiratory tract. A natural variant of the 1918 virus, called NY18, did not have the same docking power or spread as readily in animal tests, Sasisekharan reported.
In the same journal, CDC's Claudia Pappas and a team of researchers that also included Tumpey identified three genes that appear to be key to the 1918 virus's virulence.
The researchers swapped multiple genes from the reconstructed virus with genes in seasonal strains of flu. They found three that appeared to boost flu's ability to multiply in human airway cells and in mice.
Armed with such information, Paulson says, researchers will be able to study a virus taken from someone in, say, Indonesia, and see whether it can explode worldwide.
"So far that hasn't happened," he says. "That we can be grateful for."